（商品説明）

有効成分：塩酸アチパメゾール5mg/ml

効能・効果：犬と猫に対する塩酸メデトミジンの作用からの復帰

塩酸アチパメゾールを有効成分とする合成α2アドレナリン受容体拮抗薬。

塩酸メデトミジンを有効成分とする鎮静・鎮痛剤の投与によって鎮静状態になっている動物を早期に正常状態に回復させる作用があります。

（使用法）

（１）犬における塩酸メデトミジンの作用からの復帰には塩酸アチパメゾールとして体重1kg当たり40〜480μg（塩酸メデトミジンの投与量の4〜6倍量）を筋肉内注射。

（２）猫における塩酸メデトミジンの作用からの復帰には塩酸アチパメゾールとして体重1kg当たり100〜600μg（塩酸メデトミジンの投与量の2〜4倍量）を筋肉内注射。

必ず獣医師の指示に従って使用して下さい。

（使用期限）

ご注文日より１年以上有効のもの

------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Atypamezole hydrochloride – 5 mg/ml・20ml  injection

Description

The liquid is colorless, transparent.

Composition

1 ml of the preparation contains:

Atypamezole hydrochloride – 5 mg

Pharmacological properties

Atypamezole hydrochloride is a selective blocker of alpha-2-adrenoreceptors that stimulates the release of noradrenaline, which is the main neurotransmitter in the central and peripheral nervous system.

This leads to stimulation, excitation of the sympathetic nervous system, stops sedative, analgesic and other effects on the cardiovascular and respiratory systems of honeydine hydrochloride or dexmedetomidine hydrochloride.

After intramuscular injection is quickly absorbed, the maximum concentration in plasma is reached in 10-15 minutes after injection. The volume of distribution (Vd) is 1-2.5 l/kg, half-life is 2-3 hours.

Atypamezole hydrochloride is metabolized in the liver, a small amount is methylated in the kidneys. Metabolites are mainly excreted in urine.

Readings

It is used for dogs and cats for complete cessation of sedative, analgesic and side effects on the cardiovascular and respiratory systems of drugs such as medetomidine hydrochloride.

Method of administration and dosage

The drug is administered intramuscularly or subcutaneously, once, after surgery or other manipulations.

The optimal dose Atypamezole hydrochloride correlates with the amount of drug  other means on the basis of medetomidine hydrochloride thus: for dogs – 1: 1, for cats – 1: 2 (dose  Atypamezole hydrochloride  half the dose medetomidine hydrochloride ).

Examples of calculating doses for various animal species are shown in the table.

Animal species Madison dose Reverson dose

Dogs 0.4 ml per  22lb (10 kg) body weight 0.4 ml per 22lb (10 kg) body weight

Cats 0.4 ml per 1.1lb (5 kg) of body weight 0.2 ml per 1.1lb  (5 kg) of body weight

Atypamezole hydrochloride   quickly returns the animal to full consciousness and shortens the period of possible cardiovascular depression and hypothermia.

Usually, the drug begins to work within 5-10 minutes after administration. In cases where the animal continues to be depressed, Atypamezole hydrochloride can be administered in the same dose again 10-15 minutes after the first application.

Cautions

Occasionally, the drug causes vomiting, drooling, shortness of breath, bowel movements. There may be isolated cases of hyperactivity and tachycardia, which quickly pass.

Cats may experience hypothermia, so after the drug is administered, the animal should be placed in a quiet room.

If the animal is treated with a combination of medetomidine and butorphanol or ketamine, Atypamezole hydrochloride  will only stop the action of medetomidine. In this case,  Atypamezole hydrochloride should be administered no earlier than 30-40 minutes after sedation. If Atypamezole hydrochloride is applied earlier, convulsions may occur.

Nonspecific central stimulants (for example, 4-aminopyridine) enhance the effect of the drug.