（商品説明）

有効成分イベルメクチン15.5mg/gとプラジクォンテル77.5mg/gが含有された馬専用の駆虫剤。

大小の円虫、毛様線虫、ギョウチュウ、回虫、首糸虫、腸糸虫、大口胃虫、ウマバエの幼虫、肺吸虫などの寄生虫駆除と抑制、オンコセルカ症などの感染症の治療と制御に有効です。

妊娠中、授乳中の雌馬だけでなく、生後２か月の子馬にも安全に使用ができます。

日本ではエクイバランゴールドと呼ばれています。

シリンジに入った製剤（ペースト剤）なので投薬が簡単です。

在庫保有不可能商品ですので、都度取り寄せ発送となりますので、お手元に届くまで１４日～２０日ほどかかります。

（ヨ－ロッパ製）

（使用法）

1.29g/100kgを目安に投与。

＜投与参考例＞

1.29g/100kg (1本のシリンジで６回分の投与量)

2.58g/200kg（１本のシリンジで３回分の投与量）

3.87g/300kg（１本のシリンジで２回分の投与量）

5.16g/400kg（１本のシリンジで１回の投与量）

6.45g/500kg(１本のシリンジで１回の投与量)

7.74g/600kg（１本のシリンジで１回の投与量）

*容器内には600kgの馬一等分に相当する量のペーストが充填してあるため、容器に付されている目盛りにより必要量を投与することが可能です。

リングを1/4回転して緩めてスライドさせリングの外筒側を馬の体重に相当する目盛りに合わせて1/4逆回転し固定します。

馬の口中に飼料がないことを確認した後、キャップを外し容器を歯と歯の間（切歯と前臼歯の間）に挿入し、舌上にペーストを押し出した後、馬の頭を数秒間、確実に持ち上げ体内に流し込みます。

（使用上の注意）

・本剤は劇薬であるため、取り扱いには十分注意し、他の医薬品や食品、飼料とは区別し、小児の手の届かない所に保管して下さい。

・直射日光、高温多湿を避け保管して下さい。

・本剤は魚及び水棲動物に何らかの生態系影響を与える可能性も示唆されていますので、地方公共団体条例に従い残った薬剤、容器を廃棄処分して下さい。

・誤って本剤を飲み込んだ場合は直ちに医師の診察を受けて下さい。

・飲食、喫煙しながらの投与はお止め下さい。

・使用後は必ずしっかり手を荒い、誤って目などに入ってしまった場合は水洗いし、本剤を皮膚や粘膜から消去して下さい。

・馬、人間問わず何らかの副作用や異常症例が見られた場合は獣医師または医師の診察を受けて下さい。

（使用期限）

ご注文時より最低１年以上有効

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Eqvalan Duo Horese Wormer Paste

Description

Oral paste. Smooth, homogeneous orange paste.

For the treatment of mixed cestode and nematode or arthropod infestations in horses.

Contra-indications

Do not use in mares producing milk for human consumption. The product has been formulated for use in horses only. Cats, dogs, especially Collies, Old English Sheepdogs and related breeds or crosses, and also turtles and tortoises may be adversely affected by the concentration of ivermectin in this product if they are allowed to ingest spilled paste or have access to used syringes.

Special warnings for each target species

Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:

- Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.

- Underdosing, which may be due to underestimation of bodyweight, misadministration of the product, or lack of calibration of the dosing device (if any).

Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.

Resistance to macrocyclic lactones (which includes ivermectin) has been reported in Parascaris equorum in horses in the EU. Therefore the use of this product should be based on local (regional, farm) epidemiological information about susceptibility of gastrointestinal nematodes and recommendations on how to limit further selection for resistance to anthelmintics.

Special precautions for use in animals

Safety studies were not conducted in foals younger than 2 months of age, or in stallions. The use of Eqvalan Duo is not recommended in these categories of animals.

Special precautions to be taken by the person administering the product.

Wash hands after use. Do not smoke, drink or eat while handling the product. This product may cause skin and eye irritation. Therefore, the user should avoid contact of the product with the skin and the eyes. In case of contact, rinse immediately with plenty of water. In the case of accidental ingestion or eye irritation after contact, seek medical advice immediately and show the package insert or the label to the physician.

Adverse reactions

Some horses with heavy infections of Onchocerca spp. microfilariae have experienced oedema and pruritus following treatment; such reactions were assumed to be the result of the death of large numbers of microfilariae. These signs resolve within a few days but symptomatic treatment may be advisable.

In cases of heavy infestations with tapeworms, signs of mild, transient colic and loose stool may be observed.

Following administration of Eqvalan Duo, there have been rare reports of inflammation of the mouth, lip and tongue, which results in various clinical signs such as oedema, hypersalivation, erythema, tongue disorder and stomatitis. These reactions have been transitory in nature, appearing within 1 hour and abating within 24 to 48 hours following administration. In case of severe oral reactions symptomatic treatment is recommended.

Use during pregnancy, lactation or lay

Studies performed in laboratory animals showed no teratogenic or embryotoxic effect of either ivermectin or praziquantel at the recommended doses during therapy.

Ivermectin-Praziquantel combination can be used after the first three months of gestation and during lactation. In the absence of clinical data in early pregnancy Eqvalan Duo can only be used in the first three months of gestation according to a risk benefit analysis by the veterinarian.

Interactions

No data available.

Amounts to be administered and administration route

The recommended dosage is 200 mcg ivermectin per kilogram of bodyweight and 1 mg praziquantel per kilogram of bodyweight corresponding to 1.29 g of paste per 100 kg bodyweight in a single administration.

Bodyweight and dosage should be accurately determined prior to treatment. The contents of one syringe will treat horses up to 600 kg. Calibrated markings are provided at 100 kg bodyweight intervals. The syringe should be adjusted to the calculated dosage by setting the ring on the appropriate place on the plunger.

Directions for use Eqvalan Duo is for oral administration only. While holding the plunger, turn the knurled ring on the plunger ¼ turn to the left and slide it so the stop ring is at the prescribed weight marking. Lock the ring in place by turning it ¼ turn to the right in order to bring the two arrows, the one visible on the ring and the one on the plunger rod, into alignment. Make sure the horse’s mouth contains no feed. Remove the cover from the tip of the syringe. Insert the syringe tip into the horse’s mouth at the interdental space and deposit the paste on the base of the tongue. Immediately raise the horse’s head for a few seconds after dosing and ensure that the paste is consumed.

Parasite control program Veterinary advice should be given on appropriate dosing programs and stock management to achieve adequate parasite control for both tapeworm and roundworm infestations.

Overdose

No antidote has been identified; however, symptomatic therapy may be beneficial.

Withdrawal periods: Meat: 30 days

Do not use in mares producing milk for human consumption.

No undesirable effects related to treatment were observed in 2 month old horses treated with Eqvalan Duo at up to three times the recommended dose and in adult horses treated at ten times the recommended dose.

Transient decreased food consumption, increased body temperature, salivation and impairment of vision were noticed in horses treated twice with an ivermectin oral paste or once with Eqvalan Duo at ten times the recommended dose (i.e., 2 mg/kg bodyweight). All changes disappeared within five days.