通常、33 mg / kgを目安に投与しますが、
5 kg 以下：1-1.5 ml
5-10 kg： 1.5-2.5 ml
10〜20 kg ：2.5〜3.5 ml
20-30 kg ：3.5-4.5 ml
30-45 kg ：4.5-5.5 ml
45 kg以上： 4.5-5.5 ml
3 kg以下： 1 ml
3〜5 kg ：1〜1.5 ml
Covinan Proligestone 100 mg 20 ml
Covinan is a hormonal preparation based on a synthetic analogue of progesterone.
The drug is a sterile white water suspension containing 100 mg of proligestone in 1 ml as an active ingredient and auxiliary components: methyl parahydroxybenzoate, propyl parahydroxybenzoate, sorbitan palmitate, polysorbate 40, lecithin, sodium citrate, potassium dihydrogen phosphate, macrogol 4000 and water for injection.
The natural hormone progesterone is produced in both sexes in the adrenal cortex, in females by luteal cells of the corpus luteum. Its function is to prepare the endometrium for the implantation of a zygote, to ensure the normal course of pregnancy, to stimulate the development of breast tissue. Its synthetic analogue (proligestone) has the property of inhibiting the secretion of luteinizing (LH) and follicle-stimulating (FSH) hormones, which are produced by the anterior pituitary gland.
The drug Covinan inhibits the synthesis of estradiol by ovarian follicles, which prevents the development of morphological and psychophysiological changes in females associated with the sexual cycle (prevents the development of estrus). Proligestone changes the physicochemical properties of mucus in the uterus, inhibits the proliferation of the endometrium and breast cells. With the introduction of the drug during sexual rest (anestrus), proligestone maintains the LH concentration at a low level, as a result of which the ovulation process becomes impossible.
Proligestone is deposited in adipose tissue and recirculated in the liver of the animal, which is associated with the long-term effect of the drug. Its maximum concentration in blood plasma after subcutaneous administration is achieved after 2 - 3.5 days and is 29 ng / ml. The drug has a weak estrogenic, insignificant corticosteroid activity and has practically no androgenic effect. Therefore, all possible risks from the use of hormonal contraceptives are minimized.
The drug is excreted mainly with bile. According to the degree of effect on the body of warm-blooded animals, the drug belongs to low-hazard substances and in recommended doses does not have a resorptive-toxic, mutagenic and sensitizing effect.
Assign to females and cats to prevent and suppress the development of estrus, prevent and terminate false pregnancy and pseudolactation.
Covinan is administered to animals strictly subcutaneously in the middle part of the skin fold, avoiding intradermal injections, subcutaneous fat deposits and scar tissue. Before use, the bottle with the drug must be shaken thoroughly, and the injection site must be treated with 70% ethyl alcohol.
For the prevention and treatment of false pregnancy and pseudolactation, the drug is administered to females once in doses: 1 ml (weighing up to 20 kg), 2 ml (weighing from 21 to 40 kg) and 3 ml (weighing more than 40 kg).
To suppress sexual desire in cats, Covinan is prescribed in a dose of 1 ml (for large cats, weighing more than 7 kg, the dose can be increased to 1.5 ml). For bitches, the dose is selected individually depending on body weight: with a weight of less than 5 kg - 1-1.5 ml each, with a weight of 5 to 10 kg - 1.5-2.5 ml each, from 10 to 20 kg - 2.5-3 each , 5 ml, from 20 to 30 kg - 3.5-4.5 ml each, from 30 to 45 kg - 4.5-5.5 ml each, from 45 to 60 kg - 5.5-6.0 ml each.
For the development of persistent anestrus (period of sexual rest), the drug is used according to the scheme: the first injection of Covinan is carried out during the period of anestrus in bitches and cats or proestrus (onset of estrus, the first 1 - 2 days) only in bitches, the second injection is done after 3 months, the third - 4 months after the second injection of the drug, and then Covinan is administered every 5 months. In those cases, if the bitches who received the drug according to the above scheme still show signs of proestrus (swelling of the genital loop, spotting from the vagina), an extra Covinan injection must be given to prevent unwanted estrus. The further scheme of application depends on the interval at which the injections were made before the appearance of undesirable signs of proestrus. If the interval between injections is 5 months,
If the interval is 4 months, then after an extraordinary injection, the scheme is corrected as follows: after 3 months there will be the next injection, then the drug is injected after 4 months and then every 5 months. For a single prevention of estrus, the drug is administered once: to bitches during anestrus, but no later than a month before the expected estrus, to cats during anestrus or diestrus (the period immediately after estrus). To suppress estrus in bitches, Covinan is administered immediately after signs of proestrus appear. At the same time, signs of proestrus disappear within 5-7 days. The restoration of the sexual cycle in bitches occurs on average in 6 - 7 months, sometimes in a period of 3 - 12 months.
For animals suffering from diabetes mellitus and metabolic diseases, the drug is used with caution. In such cases, it is necessary to monitor the level of glucose and other elements in the blood and urine.
The use of the drug is contraindicated in females and cats who have had diseases of the genitourinary system, as well as if they have prolonged vaginal discharge of unclear etiology, females who received estrogens or progestogens for the treatment of false puberty.
Covinan is not used in pregnant and lactating females and during estrus. It is undesirable to use the drug in bitches before the first estrus and in the later stages of proestrus.
In extremely rare cases, the development of pyometritis, hyperplasia of the endometrium and breast tissue, increased appetite and weight gain and general lethargy are possible. There may be slight discoloration, hair loss, and tenderness at the injection site. The likelihood of side effects is significantly increased in cases where animals have been used other progesterone analogues.
Store in a dry, protected from direct sunlight and out of reach of children and animals, separate from food and feed at a temperature of 2 В° C to 25 В° C. Vials from under the drug must be disposed of 28 days after opening. The shelf life is 3 years.
Produced in 20ml glass bottles.
hormonal drug designed to inhibit sexual desire in bitches and cats, for the prevention and treatment of false pregnancy and pseudolactation in bitches
コビナン（プロリゲストン100mg）20ml注射液／Covinan Proligestone 100 mg 20 ml
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